Research | The science behind Wave Neuroscience's technology

MeRT-005-B- Clinical Trial to Evaluate the Safety and Efficacy of MeRT Treatment in Post-Traumatic Stress Disorder

Status

Completed

Clinical Trials.gov ID

NCT02990793

Study Start

April 4, 2022

Study Completion

November 4, 2025

Study Sponsor

Texas A&M

Enrollment

158

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eTMS-PTSD-001- EEG Personalized Transcranial Magnetic Stimulation (eTMS) (MeRT) for Post-Traumatic Stress Disorder

Status

Completed

Clinical Trials.gov ID

NCT06081309

Study Start

November 20, 2023

Study Completion

May 16, 2024

Study Sponsor

Wright State University

Enrollment

30

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eTMS (MeRT) for Veterans and First Responders With PTSD

Status

Currently Recruiting

Clinical Trials.gov ID

NCT06294106

Study Start

June 10, 2024

Study Completion

April 1, 2026

Study Sponsor

Virginia Polytechnic Institute and State University

Enrollment

20

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eTMS-PTSD-001 Stage 2- EEG-based Personalized Transcranial Magnetic Stimulation (eTMS) to Treat Post-Traumatic Stress Disorder

Status

Currently Recruiting

Clinical Trials.gov ID

NCT06892028

Study Start

February 12, 2025

Study Completion

January 31, 2026

Study Sponsor

Wright State University

Enrollment

110

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Individually guided neuromodulation in special operator veterans with symptoms of PTSD and traumatic brain injury: preliminary data from a chart review

Publication Date

2025

Publication

Frontiers in Neurology

Authors

B. Christopher Frueh, Celeste Crowder, Alexander Taghva

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Short report on a distinct electroencephalogram endophenotype for MTHFR gene variation co-occurring in autism spectrum disorder

Publication Date

2024

Publication

Sage Journals

Authors

Ezedinma U, Jones E, Ring A, Miller S, Ladhams A, Fjaagesund S, Downer T, Campbell G, Oprescu F.

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A Retrospective Chart Review to Assess the Impact of Alpha-Guided Transcranial Magnetic Stimulation on Symptoms of PTSD and Depression in Active-Duty Special Operations Service Members.

Publication Date

2024

Publication

Frontiers in Psychiatry

Authors

Bailar-Heath M, Burke R, Thomas D, Morrow C.

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Decreased Resting-State Alpha Self-Synchronization in Depressive Disorder

Publication Date

2023

Publication

Sage Journals

Authors

Yousef Mohammadi, Mohadeseh Shafiei Kafraj, Carina Graversen, Mohammad Hassan Moradi

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Posttraumatic stress disorder is associated with α dysrhythmia across the visual cortex and the default mode network.

Publication Date

2022

Publication

eNeuro

Authors

Clancy KJ, Andrzejewski JA, Simon J, Ding M, Schmidt NB, Li W.

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Outcomes from Individual Alpha Frequency Guided Repetitive Transcranial Magnetic Stimulation in Children with Autism Spectrum Disorder – A Retrospective Chart Review

Publication Date

2022

Publication

Child Psychiatry & Human Development

Authors

Ezedinma U, Swierkowski P, Fjaagesund S.

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Individual alpha frequency proximity associated with repetitive transcranial magnetic stimulation outcome: An independent replication study from the ICON-DB consortium.

Publication Date

2021

Publication

Clinical Neurophysiology

Authors

Roelofs CL, Krepel N, Corlier J, Carpenter LL, Fitzgerald PB, Daskalakis ZJ, Tendolkar I, Wilson A, Downar J, Bailey NW, Blumberger DM.

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Predictors of response to synchronized transcranial magnetic stimulation for major depressive disorder.

Publication Date

2019

Publication

Depression and Anxiety

Authors

Philip NS, Leuchter AF, Cook IA, Massaro J, Goethe JW, Carpenter LL.

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Repetitive Transcranial Magnetic Stimulation (rTMS) in Treatment Resistant Depression: Retrospective Data Analysis from Clinical Practice

Publication Date

2019

Publication

Open Journal of Depression

Authors

Griffiths C, Da Silva K, de Vail R, O'Neill-Kerr A.

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The relationship between individual alpha peak frequency and clinical outcome with repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder (MDD)

Publication Date

2019

Publication

Brain Stimulation

Authors

Corlier J, Carpenter LL, Wilson AC, Tirrell E, Gobin AP, Kavanaugh B, Leuchter AF.

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Brain activity and clinical outcomes in adults with depression treated with synchronized transcranial magnetic stimulation: an exploratory study.

Publication Date

2019

Publication

Neuromodulation

Authors

Cook IA, Wilson AC, Corlier J, Leuchter AF.

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Magnetic e-Resonant Therapy Alleviates Combat Related Posttraumatic Stress Disorder. 88th Annual Scientific Meeting of the Aerospace Medical Association.

Publication Date

2017

Publication

Aerospace Medicine and Human Performance

Authors

Gentry J, Bates G, Biedermann S, Jin Y, Zhang J.

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Alpha oscillations and their impairment in affective and post-traumatic stress disorders

Publication Date

2016

Publication

Neuroscience and Biobehavioral Reviews

Authors

Eidelman-Rothman M, Levy J, Feldman R.

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Efficacy and safety of low-field synchronized transcranial magnetic stimulation (sTMS) for treatment of major depression. Brain stimulation.

Publication Date

2015

Publication

Brain Stimulation

Authors

Leuchter AF, Cook IA, Feifel D, Goethe JW, Husain M, Carpenter LL, Thase ME, Krystal AD, Philip NS, Bhati MT, Burke WJ, Howland RH, Sheline YI, Aaronson ST, Iosifescu DV, O’Reardon JP, Gilmer WS, Jain R, Burgoyne KS, Phillips B, Manberg PJ, Massaro J, Hunter AM, Lisanby SH, George MS.

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Magnetic Resonance Therapy Improves Clinical Phenotype and EEG Alpha Power in Posttraumatic Stress Disorder

Publication Date

2015

Publication

Trauma Monthly

Authors

Taghva A, Silvetz R, Ring A, Keun-young AK, Murphy KT, Liu CY, Jin Y.

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The relationship between brain oscillatory activity and therapeutic effectiveness of transcranial magnetic stimulation in the treatment of major depressive disorder

Publication Date

2013

Publication

Frontiers in Human Neuroscience

Authors

Leuchter AF, Cook IA, Jin Y, Phillips B.

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Clinical Trials

MeRT-005-B- Clinical Trial to Evaluate the Safety and Efficacy of MeRT Treatment in Post-Traumatic Stress Disorder

Texas A&M

158

eTMS-PTSD-001- EEG Personalized Transcranial Magnetic Stimulation (eTMS) (MeRT) for Post-Traumatic Stress Disorder

Wright State University

30

eTMS (MeRT) for Veterans and First Responders With PTSD

Virginia Polytechnic Institute and State University

20

eTMS-PTSD-001 Stage 2- EEG-based Personalized Transcranial Magnetic Stimulation (eTMS) to Treat Post-Traumatic Stress Disorder

Wright State University

110

Publications

Individually guided neuromodulation in special operator veterans with symptoms of PTSD and traumatic brain injury: preliminary data from a chart review

B. Christopher Frueh, Celeste Crowder, Alexander Taghva

Short report on a distinct electroencephalogram endophenotype for MTHFR gene variation co-occurring in autism spectrum disorder

Ezedinma U, Jones E, Ring A, Miller S, Ladhams A, Fjaagesund S, Downer T, Campbell G, Oprescu F.

A Retrospective Chart Review to Assess the Impact of Alpha-Guided Transcranial Magnetic Stimulation on Symptoms of PTSD and Depression in Active-Duty Special Operations Service Members.

Bailar-Heath M, Burke R, Thomas D, Morrow C.

Decreased Resting-State Alpha Self-Synchronization in Depressive Disorder

Yousef Mohammadi, Mohadeseh Shafiei Kafraj, Carina Graversen, Mohammad Hassan Moradi

Posttraumatic stress disorder is associated with α dysrhythmia across the visual cortex and the default mode network.

Clancy KJ, Andrzejewski JA, Simon J, Ding M, Schmidt NB, Li W.

Outcomes from Individual Alpha Frequency Guided Repetitive Transcranial Magnetic Stimulation in Children with Autism Spectrum Disorder – A Retrospective Chart Review

Ezedinma U, Swierkowski P, Fjaagesund S.

Individual alpha frequency proximity associated with repetitive transcranial magnetic stimulation outcome: An independent replication study from the ICON-DB consortium.

Roelofs CL, Krepel N, Corlier J, Carpenter LL, Fitzgerald PB, Daskalakis ZJ, Tendolkar I, Wilson A, Downar J, Bailey NW, Blumberger DM.

Predictors of response to synchronized transcranial magnetic stimulation for major depressive disorder.

Philip NS, Leuchter AF, Cook IA, Massaro J, Goethe JW, Carpenter LL.

Repetitive Transcranial Magnetic Stimulation (rTMS) in Treatment Resistant Depression: Retrospective Data Analysis from Clinical Practice

Griffiths C, Da Silva K, de Vail R, O'Neill-Kerr A.

The relationship between individual alpha peak frequency and clinical outcome with repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder (MDD)

Corlier J, Carpenter LL, Wilson AC, Tirrell E, Gobin AP, Kavanaugh B, Leuchter AF.

Brain activity and clinical outcomes in adults with depression treated with synchronized transcranial magnetic stimulation: an exploratory study.

Cook IA, Wilson AC, Corlier J, Leuchter AF.

Magnetic e-Resonant Therapy Alleviates Combat Related Posttraumatic Stress Disorder. 88th Annual Scientific Meeting of the Aerospace Medical Association.

Gentry J, Bates G, Biedermann S, Jin Y, Zhang J.

Alpha oscillations and their impairment in affective and post-traumatic stress disorders

Eidelman-Rothman M, Levy J, Feldman R.

Efficacy and safety of low-field synchronized transcranial magnetic stimulation (sTMS) for treatment of major depression. Brain stimulation.

Leuchter AF, Cook IA, Feifel D, Goethe JW, Husain M, Carpenter LL, Thase ME, Krystal AD, Philip NS, Bhati MT, Burke WJ, Howland RH, Sheline YI, Aaronson ST, Iosifescu DV, O’Reardon JP, Gilmer WS, Jain R, Burgoyne KS, Phillips B, Manberg PJ, Massaro J, Hunter AM, Lisanby SH, George MS.

Magnetic Resonance Therapy Improves Clinical Phenotype and EEG Alpha Power in Posttraumatic Stress Disorder

Taghva A, Silvetz R, Ring A, Keun-young AK, Murphy KT, Liu CY, Jin Y.

The relationship between brain oscillatory activity and therapeutic effectiveness of transcranial magnetic stimulation in the treatment of major depressive disorder

Leuchter AF, Cook IA, Jin Y, Phillips B.