Active Clinical Trials

Wave Neuro's active clinical trials

sTMS for Substance Use-disordered Veterans

VA Office of Research and Development - The goal of this proposal is to evaluate preliminary participant response to a pilot, controlled, feasibility study to evaluate changes in craving, substance use, and quality of life after 6 weeks of a low-risk non-invasive brain stimulation technique, called Synchronized Transcranial Magnetic Stimulation (sTMS), compared to sham, in Veterans with a substance use disorder (SUD).

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Evaluate the Safety and Efficacy of MeRT Treatment in Persistent Post-Concussive Symptoms (PPCS)

MeRT-TBI-005 is a prospective, double blind, randomized, sham-controlled, parallel group, adaptive clinical trial designed to evaluate the efficacy of EEG/EKG-guided MeRT in active duty military service men and women, reservists on active duty orders, and military retirees with Persistent Post-Concussion Symptoms (PPCS) and Traumatic Brain Injury.

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Completed Research

Research proving the effectiveness of Wave Neuroscience technology

2020

A Chart Review to Assess the Response of Veterans Suffering from Tinnitus to Alpha Burst Transcranial Magnetic Stimulation

Eighteen of the 23 patients reported significant improvements in tinnitus symptoms. For patients reporting improvements, there was an average 44% reduction in tinnitus symptoms and a 60% reduction in NSI scores following intervention.

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2019

Brain Activity and Clinical Outcomes in Adults With Depression Treated With Synchronized Transcranial Magnetic Stimulation: An Exploratory Study

This study identified that target sites related to depression can be actively targeted and engaged using sTMS.

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2019

sTMS for posttraumatic stress disorder and comorbid major depression

This study found that active sTMS yielded greater reductions in PTSD and MDD symptoms than sham sTMS.

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2018

Predictors of response to synchronized transcranial magnetic stimulation for major depressive disorder

This study found that participants with greater severity of depression and higher anxiety had superior responses to synchronized transcranial magnetic stimulation (sTMS).

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2017

Electric field characteristics of low-field sTMS

This study found that sTMS has a maximum induced electric field strength of approximately 0.02 Vm, which is an order of magnitude lower compared to those delivered by traditional rTMS

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2016

The Potential of Magnetic Resonant Therapy in Children with Autism Spectrum Disorder

The study found that guided TMS’s effect on aberrant EEG biomarkers for PTSD and Depression might make it uniquely suited to improve disrupted networks in autism patients.

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2015

sTMS Efficacy and Safety of Low-field sTMS for Treatment of Major Depression

This study demonstrated that when accurately & consistently delivered, low-field magnetic energy synchronized to a subjects individualized alpha frequency is considered an effective treatment for MDD.

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2015

Magnetic Resonance Therapy Improves Clinical Phenotype and EEG Alpha Power in Posttraumatic Stress Disorder

This open-label study found that over 4 weeks, Veterans with PTSD treated with guided TMS saw significant improvements in clinical scales & EEG biomarkers indicative of functional brain activity disruption.

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2014

A pilot study of the use of EEG-based sTMS for treatment of Major Depression

This study demonstrated that patients receiving sTMS had a statically significant decrease in Major Depressive Disorder (MDD) symptoms over those subjects in the sham group.

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2013

The affect of TMS on brain oscillations and their impact on the treatment of Major Depressive Disorder (MDD)

This study summarizes evidence that the therapeutic effectiveness of rTMS can be improved by synchronizing stimulation to the patient’s individualized alpha frequency. This approach possibly enhances neuroplasticity, normalizes blood flow, and may eliminate symptoms related to depression symptoms.

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